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A pilot randomised trial comparing short course infusional 5-Fluorouracil (5FU) with 5FU + Leucovorin as adjuvant therapy for resected colorectal carcinoma

A pilot randomised trial comparing short course infusional 5-Fluorouracil (5FU) with 5FU + Leucovorin as adjuvant therapy for resected colorectal carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN92933910
Enrollment
Unknown
Registered
2002-08-19
Start date
1993-08-19
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal carcinoma Cancer

Interventions

1. 5FU (Protracted venous infusion [PVI]) 12 weeks (300 mg/m2) 2. 5FU + Folinic Acid (NCCTG) (425 mg/m2 + 20 mg/m2) every 28 days for six courses

Sponsors

The Royal Marsden NHS Foundation Trust (UK)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adenocarcinoma - Dukes stage B or C 2. No evidence of residual or metastatic disease assessed at surgery, clinically or radiologically

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration—

Secondary

MeasureTime frame
Not provided at time of registration—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026