Joint distraction in the treatment of knee osteoarthritis: efficacy and underlying mechanisms

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN92846059

Enrollment

Registered

2007-02-26

Start date

2004-07-28

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis Musculoskeletal Diseases Arthropathies

Interventions

Joint distraction applies temporary (two months) relief of mechanical wear and tear of the articular cartilage surfaces forming a joint. Nutrition of the cartilage is maintained due to intra-articular

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age less than 55 years 2. Osteoarthritis, primary in the tibio-femoral joint, uni or bilateral 3. Severe osteoarthritis considered for joint replacement surgery/osteotomy

Exclusion criteria

Exclusion criteria: 1. Osteoarthritis in both knees 2. Primary retro-patellar osteoarthritis 3. Deviation of the mechanical axis greater than 10 º (independent of cartilage damage) 4. Primary intra-articular inflammation 5. Psychological problems, not allowing two months distraction

Design outcomes

Primary

Measure	Time frame
Pain (according to the The Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC])	—

Secondary

Measure	Time frame
Functional disability (according to the WOMAC)	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026