Impact of contact precautions for preventing bacterial (Pseudomonas aeruginosa) infections in intensive care units

Do contact precautions reduce the incidence of ICU-acquired Pseudomonas aeruginosa infections? The DPCPYO cluster-randomised crossover trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN92710225

Enrollment

5000

Registered

2020-06-19

Start date

2012-01-01

Completion date

Unknown

Last updated

2020-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of ICU-acquired Pseudomonas aeruginosa infections Infections and Infestations

Interventions

Ten French ICUs were randomly assigned (1:1) to sequence 0-1 (6-month control period /3-month wash-out period/6-month intervention period) or sequence 1-0 (6-month intervention period/3-month wash-out

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult (> 15-year old patients) admitted for more than 24 hours in ICU

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
Rate of ICU-acquired Pseudomonas aeruginosa infections measured using routine diagnostic samples (blood, bronchoalveolar lavage, urine…) with routine clinical surveillance of patients that remained unchanged throughout the study period. Patients were screened for P. aeruginosa carriage (throat swab/tracheal aspirate and rectal swab) upon ICU admission (= 48 h) and once a week thereafter.	—

Secondary

Measure	Time frame
1. Rate of Pseudomonas aeruginosa acquisition (acquired infection and/or colonisation) measured as above. 2. Clonal relatedness of P. aeruginosa isolates measured using the Simpson diversity index and transmission index of Pseudomonas aeruginosa isolates within ICUs throughout the study.	—

Countries

France

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 17, 2026