Toxic metals from diet in pregnancy: the PEAR Study (pregnancy, the environment and nutrition)

Dietary exposures to toxic metals in pregnancy: the PEAR Study (Pregnancy, the Environment And nutRition)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN92638336

Enrollment

300

Registered

2023-02-27

Start date

2023-04-01

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exposure to toxic metals in pregnancy Pregnancy and Childbirth

Interventions

Observational study: during pregnancy measurement of biomarkers for lead, mercury and arsenic in blood and urine samples, collection of dietary data, lifestyle and environment questionnaires

Eligibility

Sex/Gender

Female

Age

18 Years to 51 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 years and over 2. Pregnant <14 weeks 3. Has internet access 4. Able to read and write English 5. Planning to have blood sample taken at 12-week screening clinic 6. Registered for care at Southmead Hospital, Bristol, UK

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
Biomarkers for lead, mercury and arsenic will be measured in whole blood and urine samples at 12 weeks.	—

Secondary

Measure	Time frame
1. Lifestyle and environment information will be collected using an online questionnaire at 12 and 32 weeks. 2. Dietary data will be collected at 12 weeks using an online data collection tool (myfood24).	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026