Kidney failure/haemodialysis Urological and Genital Diseases Renal failure
Conditions
Interventions
All patients were treated for 4 weeks with "4 hours of haemodialysis" three times per week for one month (the run-in period). Then all patients were randomised to receive each of the four noted treatm
Sponsors
Kidney Foundation of Canada (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients on a stable regimen of haemodialysis greater than or equal to 3 months 2. Dry weight greater than or equal to 80 kg 3. Kt/V less than 1.2 on two occasions in the previous 6 months or requirement for greater than 12 hours of haemodialysis per week because of a history of inadequate dialysis 4. Blood flow rate greater than 350 ml/min through a well functioning access 5. Aged greater than 18, both sexes
Exclusion criteria
Exclusion criteria: 1. Scheduled renal transplant in the next 6 months 2. Contraindication to intradialytic anticoagulation 3. Requirement for greater than 4.5 hours of haemodialysis three times per week for the purpose of volume removal due to excessive interdialytic weight gains or intradialytic hypotension/cramping 4. Failure to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 'End-Stage Renal Disease (ESRD) symptoms' domain of the Kidney Disease Quality of Life Short Form (KDQOL-SF) measured at the end of each 6-week treatment session. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Health Utility Index mark 2 (HUI 2) utility score, evaluated during the last week of the treatment (i.e. during week 6 of each treatment period) 2. Exploratory measures of Health-Related Quality Of Life (HRQOL): other domains of the Kidney Disease Quality of Life (KDQOL) and 36-item Short Form health survey (SF-36), evaluated during the last week of the treatment (i.e. during week 6 of each treatment period) | — |
Countries
Canada
Outcome results
None listed