Do abnormalities in the control of brain blood flow account for dizziness on standing or after meals in older people?

Do abnormalities in dynamic cerebral autoregulation underlie the pathophysiology of the common causes of syncope in older people?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN92525381

Enrollment

120

Registered

2012-03-19

Start date

2011-02-15

Completion date

Unknown

Last updated

2018-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Syncope Signs and Symptoms Syncope and collapse

Interventions

Participants shall have height, weight, medical history taken with a basic examination of the cardiovascular, respiratory and neurological system. Orthostatic grading score shall be obtained by answer

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age >= 60 years, male or female

Exclusion criteria

Exclusion criteria: 1. Known autonomic neuropathy 2. Irregular heart rhythm such as atrial fibrillation 3. On drugs known to affect autonomic function 4. Uncontrolled high blood pressure 5. Stroke 6. Known carotid artery stenosis 7. Severe cognitive impairment 8. Severe physical impairment

Design outcomes

Primary

Measure	Time frame
Autoregulatory index for baseline, at 1 and 3 minute of tilt and the last 3 and 1 minute of tilt, the duration of which is dependent on the presence or absence of symptoms	—

Secondary

Measure	Time frame
1. Arterial stiffness 2. Baroreceptor sensitivity	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026