Does providing low-medium flow of oxygen to the non-ventilated lung during one-lung ventilation prevent lung injury?

Effect of continuous administration of low-medium flow oxygen to the non-ventilated lung during one-lung ventilation surgery on blood gas analysis and oxidative stress response in lung tissue of tumor patients: A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN92523174

Enrollment

Registered

2019-10-22

Start date

2017-01-02

Completion date

Unknown

Last updated

2019-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of acute lung injury in patients undergoing video-assisted thoracoscopic surgery for lung tumor requiring one-lung ventilation Respiratory

Interventions

Each of the patients who enrolled in the study was randomly divided by the anesthetist into one of two groups by random number table method: experimental group (Group O, continued low-medium flow oxyg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Physical status I or II according to the American Society of Anesthesiologists 2. Age 18-64 years 3. Scheduled to undergo video-assisted thoracoscopic surgery requiring one-lung ventilation (OLV) for the treatment of lung tumor

Exclusion criteria

Exclusion criteria: 1. Surgery for more than 4 h 2. Need to stop single lung ventilation during surgery to restore dual lung ventilation to maintain oxygen saturation >90% 3. Patients with immune disease, upper respiratory tract infection, adrenal dysfunction, recent radiotherapy or chemotherapy, pleural effusion, asthma or oral hormonal therapy within 3 months prior to surgery 4. Preoperative pulmonary function tests measured values lower than the minimum required value of various lung resection preoperative pulmonary function test (FEV1 <70% of predicted value)

Design outcomes

Primary

Measure	Time frame
1. Superoxide dismutase (SOD) level (as a marker of oxidative stress) in lung tumor tissue biopsy from the non-ventilated lung assessed by chemical colorimetry 2. Malondialdehyde (MDA) level (as a marker of oxidative stress) in lung tumor tissue biopsy from the non-ventilated lung assessed by by chemical colorimetry 3. Heme oxygenase-1 (HO-1) expression (as a marker of the body's response to vascular inflammation) in lung tumor tissue biopsy from the non-ventilated lung detected by Western blot	—

Measure

Time frame

1. Superoxide dismutase (SOD) level (as a marker of oxidative stress) in lung tumor tissue biopsy from the non-ventilated lung assessed by chemical colorimetry 2. Malondialdehyde (MDA) level (as a marker of oxidative stress) in lung tumor tissue biopsy from the non-ventilated lung assessed by by chemical colorimetry 3. Heme oxygenase-1 (HO-1) expression (as a marker of the body's response to vascular inflammation) in lung tumor tissue biopsy from the non-ventilated lung detected by Western blot

—

Secondary

Measure	Time frame
Blood gas analysis of radial artery and internal jugular vein collected at induction of anesthesia (T1), 30 min after start of OLV (T2), 1 h after start of OLV (T3) and 2 h after start of OLV (T4)	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026