A study to determine if a new pacemaker function called Multipoint Pacing (MPPTM) can improve exercise performance and heart synchronisation during exercise

Assessing the effect of multipoint pacing in cardiac resynchronization therapy with AV node block on QRS duration and exercise capacity

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN92450031

Enrollment

Registered

2025-01-16

Start date

2024-09-01

Completion date

Unknown

Last updated

2025-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multi point pacing in cardiac resynchronisation therapy with AV node block Circulatory System

Interventions

We will use a prospective single-centre randomized double-blinded crossover study to investigate our hypothesis. Twenty participants will be enrolled and asked to attend the Cardiovascular Clinical R

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =18 years 2. Willing and able to give informed consent 3. Patients with existing CRT devices able to utilise the MPP™ algorithm, implanted =6 months and under follow up at OUH NHS Foundation Trust 4. Sinus rhythm and PR interval >250 ms, or higher degrees of heart block 5. Able to exercise to perform CPET

Exclusion criteria

Exclusion criteria: 1. Pregnancy or breastfeeding 2. Persistent or permanent atrial fibrillation or atrial tachycardia 3. PR interval <250 ms 4. Chronotropic incompetence, defined as the use of a rate-response algorithm or =80% atrial pacing 5. Any concurrent condition contraindicating the use of CPET 6. Any impediment to communication which, in the opinion of the investigator, might prevent the investigator communicating effectively with the patient during the study (including inability to speak English)

Design outcomes

Primary

Measure	Time frame
QRS duration measured using an assessment of exercise ECG intervals performed automatically by the recording software (Custo-Med). All beats suitable for analysis in the last 10 seconds of each exercise stage are automatically selected. QRS duration is then measured from the earliest to the latest markers on any lead of the 12-lead ECG (global QRSd). Recording occurs at baseline and through different stages of exercise up to peak VO2 during a cardiopulmonary exercise test (CPET).	—

Measure

Time frame

QRS duration measured using an assessment of exercise ECG intervals performed automatically by the recording software (Custo-Med). All beats suitable for analysis in the last 10 seconds of each exercise stage are automatically selected. QRS duration is then measured from the earliest to the latest markers on any lead of the 12-lead ECG (global QRSd). Recording occurs at baseline and through different stages of exercise up to peak VO2 during a cardiopulmonary exercise test (CPET).

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Secondary

Measure	Time frame
1. Exercise performance will be quantified during cardiopulmonary exercise testing (CPET) using standardised measures including: VO2 max, VO2 at the aerobic threshold, VE/VCO2 slope, OUES slope, VO2/HR, heart rate, RER, and exercise duration. Blood lactate sampling will be performed at rest, peak exertion and 15 minutes into recovery. 2. Subjective effort will be quantified using the Borg-RPE scale through different stages of exercise up to peak VO2.	—

Measure

Time frame

1. Exercise performance will be quantified during cardiopulmonary exercise testing (CPET) using standardised measures including: VO2 max, VO2 at the aerobic threshold, VE/VCO2 slope, OUES slope, VO2/HR, heart rate, RER, and exercise duration. Blood lactate sampling will be performed at rest, peak exertion and 15 minutes into recovery. 2. Subjective effort will be quantified using the Borg-RPE scale through different stages of exercise up to peak VO2.

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Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026