A randomised controlled trial of the benefits of exercise early in the management of Type 2 diabetes

Conditions

Type 2 diabetes Nutritional, Metabolic, Endocrine Non-insulin dependent diabetes mellitus

Garbutt J, England C, Jones AG, Andrews RC, Salway R, Johnson L.

2022-04-184 citations

“I’ve made this my lifestyle now”: a prospective qualitative study of motivation for lifestyle change among people with newly diagnosed type two diabetes mellitus

Simon J. Sebire, Zoi Toumpakari, Katrina Turner, Ashley R Cooper, Angie S Page et al. (7 authors)

BMC Public Health2018-01-3185 citations

10.1186/s12889-018-5114-5

Dietary changes and associations with metabolic improvements in adults with type 2 diabetes during a patient-centred dietary intervention: an exploratory analysis

Clare England, Janice L. Thompson, Russell Jago, Ashley R Cooper, Robert Andrews

BMJ Open2014-06-018 citations

10.1136/bmjopen-2014-004953

Effect of Diet or Diet Plus Physical Activity Versus Usual Care on Inflammatory Markers in Patients with Newly Diagnosed Type 2 Diabetes: The Early ACTivity In Diabetes (ACTID) Randomized, Controlled Trial

Dylan Thompson, Jean‐Philippe Walhin, Alan M. Batterham, Keith Stokes, Ashley R Cooper et al. (6 authors)

Journal of the American Heart Association2014-05-0939 citations

10.1161/jaha.114.000828

Multiple behaviour change intervention and outcomes in recently diagnosed type 2 diabetes: the ADDITION-Plus randomised controlled trial.

Griffin SJ, Simmons RK, Prevost AT, Williams KM, Hardeman W, Sutton S, Brage S, Ekelund U, Parker RA, Wareham NJ, Kinmonth AL, ADDITION-Plus study team.

2014-04-2428 citations

10.1007/s00125-014-3236-6

Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial.

Andrews RC, Cooper AR, Montgomery AA, Norcross AJ, Peters TJ, Sharp DJ, Jackson N, Fitzsimons K, Bright J, Coulman K, England CY, Gorton J, McLenaghan A, Paxton E, Polet A, Thompson C, Dayan CM.

2011-06-24198 citations

10.1016/s0140-6736(11)60442-x

Interventions

1. Intensive dietary intervention 2. Increased exercise and intensive dietary intervention 3. Control: Usual Care Individuals recruited into all 3 arms

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: This a multicentre trial recruiting 750 participants from across the South West of England. Individuals must satisfy the following criteria before they can be considered eligible: 1. Type 2 diabetes mellitus (T2DM) as defined by: body mass index (BMI) >25, no ketosis, no significant weight loss prior to diagnosis, aged above 30 at diagnosis 2. Between 5 and 8 months from clinical diagnosis of T2DM

Exclusion criteria

Exclusion criteria: 1. Age over 80 at diagnosis 2. HbA1c of greater than 10% 3. Blood pressure greater than 180/100 4. Low-density lipoprotein (LDL) greater than 4 5. Patients already receiving a maximum dose of a sulphonylurea 6. Have a current diagnosis of unstable angina 7. Have had a myocardial infarction within the previous three months 8. Unable to increase their physical activity 9. Subject is pregnant or is of childbearing age and not surgically sterile, 2 years postmenopausal or does not practice one method of contraception

Design outcomes

Primary

Measure	Time frame
Glycaemic control as measured by HbA1c and systolic and diastolic blood pressure, at 6 months.	—

Secondary

Measure	Time frame
Lipids, insulin resistance, weight/body composition, and amount of medication required to control diabetes and blood pressure at 12 months.	—

Countries

England, United Kingdom

Outcome results

None listed