Chronic periaortitis, also known as Ormond’s disease or retroperitoneal fibrosis is a rare disease of unknown etiology with pathological features of vascular inflammation and fibrosis. Circulatory System
Conditions
Interventions
We compared arterial stiffness and endothelial function in 16 patients with chronic periaortitis to age- and sex-matched hypertensive and healthy controls in a 1:1 distribution. Aortic stiffness was a
Sponsors
Inselspital University Hospital Bern (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients: patients with a diagnosis of chronic periaortitis that were followed at our outpatient clinic for Nephrology and Hypertension and patients with known arterial hypertension that were followed at our outpatient clinic for Nephrology and Hypertension, matched for age and sex in a 1:1 fashion. Healthy volunteers: healthy volunteers from the community and clinic staff, matched 1:1 for age and sex.
Exclusion criteria
Exclusion criteria: Patients with atrial fibrillation and other cardiac arrhythmias that interfered with study measurements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial stiffness, measured by pulse wave velocity (PWV). PWV was recorded in a single session, using a Pulse Trace PWV© (Micro Medical Ltd, Rochester, Kent, UK) with a 4-MHz continuous wave directional Doppler pencil probe. Pulse Trace PWV© calculates the time lag between the R wave of the electrocardiogram and the arrival of the arterial pulse wave at 2 different sites, thus inferring pulse wave velocity. First, electrodes for an electrocardiogram are placed, followed by placing the Doppler probe over (1) the right carotid artery and (2) the right or left femoral artery. The position of the Doppler probe is optimized at each site to achieve a signal of sufficient quality (i.e. stable pulse waveform). About 10 systolic peaks are recorded at both sites to obtain a mean time lag at the carotid artery and at the femoral artery. The distance between the 2 detection sites is measured. | — |
Secondary
| Measure | Time frame |
|---|---|
| Digital volume pulse (DVP) as a measure for endothelial function, blood pressure, heart rate and pulse pressure. DVP was measured photoplethysmographically in the same single session as PWV, using the Pulse Trace© Pulse Contour Analysis device (Micro Medical Ltd, Rochester, Kent, UK). The probe were placed on the index finger of the dominant hand. Pulse contour waves recorded over a period of 10 seconds were averaged by the device to a single waveform. Blood pressure was measured while participants were recumbent for at least 10 minutes. | — |
Countries
Switzerland
Outcome results
None listed