Untreated Cervical Intraepithelial Neoplasia, grade 2 (CIN2), a follow-up study of young patients

Untreated CIN2 follow-up study of young patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN91953024

Enrollment

300

Registered

2013-11-08

Start date

2013-10-14

Completion date

Unknown

Last updated

2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Intraepithelial Neoplasia, grade 2 Urological and Genital Diseases Moderate cervical dysplasia

Interventions

At baseline: 1. Patient information, written consent 2. Colposcopy 3. Sample for HPV genotyping At 6 months: 1. Colposcopy 2. Cytology 3. Punch biopsy/biopsies for methylation studies and according t

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Age 18 to 30 years at first study visit 2. Biopsy-confirmed diagnosis of CIN2

Exclusion criteria

Exclusion criteria: 1. Cervical cancer 2. High-grade CIN (CIN3), high-grade vulvar or vaginal dysplasia (VIN 3, VAIN 3) 3. Previous LEEP of CIN3 4. A very large or not completely visible CIN2 lesion in colposcopy 5. Pregnancy or breastfeeding 6. Human immunodeficiency virus (HIV)-positive 7. Immunosuppressive medication 8. Language difficulties (patients who do not speak sufficient Finnish or English)

Design outcomes

Primary

Measure	Time frame
Histological regression to normal at 24 months follow-up	—

Secondary

Measure	Time frame
1. Histological regression to =CIN1 at 24 months 2. Histological progression to > CIN2 3. HPV negativity at 24 months	—

Countries

Finland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026