A randomised controlled trial to compare auto variable positive airway pressure ventilation with conventional non-invasive positive pressure ventilation in the treatment of hypercapnic ventilatory failure in chronic obstructive pulmonary disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN91892415

Enrollment

Registered

2006-06-28

Start date

2005-12-16

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease (COPD) Respiratory Chronic obstructive pulmonary disease (COPD)

Interventions

There are two groups: the first will receive either auto variable positive airway pressure ventilation (auto VPAP) and the second group will receive standard non-invasive positive pressure ventilation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) 2. Forced expiratory volume in one second (FEV1) 20 pack years 4. Hypercapnic ventilatory failure

Exclusion criteria

Exclusion criteria: 1. Age > 80 2. Body Mass Index (BMI) > 40

Design outcomes

Primary

Measure	Time frame
Nocturnal oxygenation	—

Secondary

Measure	Time frame
Pulmonary function	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026