Coartem or Coarnate for uncomplicated malaria and parasite carriage in Rwanda

An open labeled randomised trial of Coartem vs. Co-Arinate for uncomplicated malaria and parasite carriage in Rwanda

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN91805477

Enrollment

900

Registered

2010-10-25

Start date

2010-09-15

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria Infections and Infestations Unspecified malaria

Interventions

Patients will be randomised to receive 1. Coartem (arthemeter lumifantrine) 5-14 kg 20 mg arthemeter+120 mg lumefantrine 2/day for 3 days 15-24 kg: 40 mg arthemeter+ 240 mg lumefantrine 2/day for 3

Eligibility

Inclusion criteria

Inclusion criteria: 1. Either sex, age > 6 months 2. Simple malaria

Exclusion criteria

Exclusion criteria: Severe malaria

Design outcomes

Primary

Measure	Time frame
Parasite clearance as per WHO guidelines: Full parasitological an clinical responses after 42 days of follow-up as measured by microscopy examination. At every follow-up visit a microscopy slide will be examined for parasites and counted against 200 whole blood count (WBC).	—

Secondary

Measure	Time frame
Gametocyte carriage: At day 0,day 1, day 7 and day 14 blood samples (50 ul on filter paper) will be collected for molecular analysis of gametocytes. After nucleic acid extraction analysis will be done with NASBA and results will be expressed as gametocytes/ul	—

Countries

Rwanda

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026