Treatment of glucose homeostasis in people at risk of type 2 diabetes. Nutritional, Metabolic, Endocrine
Conditions
Interventions
All participants completed two 6-day interventions with a wash-out of 7 days. Each 6-day intervention consisted of an initial 3-day habitual dietary intake phase (Non-TRE i.e. the control condition),
Early-TRE) or late (12pm - 8pm
Late-TRE). In which order a participant followed the two 6-day interventions was randomised. During TRE phase, participants were provided with foods to follow a eucaloric energy intake. During the non
Sponsors
Manchester Metropolitan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male and female adults aged 45-60 years 2. Classed as clinically overweight or obese (BMI =25 kg/m²) 3. Sedentary lifestyle (not meeting physical activity recommendations of 150 minutes of moderate to vigorous exercise per week 4. Typical dietary consumption pattern over the entire day (>14 h/day)
Exclusion criteria
Exclusion criteria: 1. Currently classed as having diabetes (HbA1c =48 mmol/mol) 2. Enrolled in another lifestyle intervention or clinical research trial 3. History of substance abuse 4. Pregnant or considering pregnancy 5. Known cancer 6. History of myocardial infarction within the previous 6 months 7. Learning disability 8. Diagnosed with an eating disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose homeostasis - assessed using continuous glucose monitoring. Specific outcomes include 3-day average of mean 24h glucose, glucose area under the curve and glycaemic variability markers. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasted cardio-metabolic blood markers (insulin, HOMA-IR, ADIPO-IR, cholesterol) taken before and after each 3-day TRE phase. | — |
Countries
England, United Kingdom
Contacts
Public ContactKelly Bowden Davies
Outcome results
None listed