Renal function and fluid turnover after infusion of saline and Ringer's acetate in elderly males

Glomerular filtration rate and fluid volume kinetics of isotonic saline versus Ringer's acetate in males scheduled for transurethral resection of the prostate

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN91152670

Enrollment

Registered

2014-06-12

Start date

2013-02-14

Completion date

Unknown

Last updated

2018-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transurethral resection of the prostate Surgery

Interventions

Infusion of two electrolyte isolations (saline and Ringer's acetate) on two different occasions. Continuous infusion of iohexol (an X-ray contrast medium that can be used to measure glomerular filtrat

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Patients scheduled for transurethral resection of the prostate due to benign enlargement of the prostate at Södersjukhuset, Stockholm, who have an indwelling bladder catheter

Exclusion criteria

Exclusion criteria: Patients with severe renal disease (serum creatinine > 120) or heart disease (ASA group III)

Design outcomes

Primary

Measure	Time frame
Glomerular filtration rate, measured using continuous infusion of iohexol during five periods of 30 minutes each, starting 30 min after the study begins and 30 min after the fluid infusion is started	—

Secondary

Measure	Time frame
Fluid volume kinetics based on blood and urine sampled during the last 3 hours of each experiment	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026