Variability in the treatment and outcomes of patients with potentially resectable pancreatic cancer Cancer
Conditions
Interventions
PACOPS is an observational cohort study for reporting trends of practice and variation in the treatment and management of pancreatic cancer across the UK and as a stable cohort from which trials can b
Sponsors
University of Birmingham
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients (aged >18 years) who are newly diagnosed with suspected or proven pancreatic cancer and are on a potentially resectable cancer pathway 2. Potentially resectable for this study is defined as any patient receiving or considered for treatment which may be potentially curative and thus includes upfront surgery and neoadjuvant pathways, regardless of the anatomical staging of the cancer 3. Ability to provide informed consent
Exclusion criteria
Exclusion criteria: Patients undergoing resection for chronic pancreatitis and for tumours arising outside the pancreas
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study will collect a range of clinical- and patient-reported outcomes. There is no explicit primary outcome measure and all of the following will be assessed: Clinician-reported outcomes 1. Resection rates of different treatment pathways in pancreatic cancer measured using data recorded in an online Case Report Form (CRF) at 6 months 2. Approaches to resectability across the UK, measured using data recorded in an online CRF at 6 months 3. Recurrence-free interval, measured using data recorded in an online CRF at 3 monthly intervals up to 24 months 4. Clinical and radiological patterns of pancreatic cancer recurrence, measured using clinical and radiological data recorded in an online CRF at 3-6 monthly intervals following surgery 5. Prognostic factors for asymptomatic pancreatic cancer recurrence, measured using data recorded in an online CRF at 3-6 monthly intervals following surgery 6. Compliance of unit practice with published NICE guidelines, measured by comparing current practice as determined by the study with NICE Guidelines at 3-6 monthly intervals following surgery Patient-reported outcomes Quality of life measured using EQ5D, EORTIC QLQ-C30, EORTIC QLQ-PAN26, EORTIC QLQCIPN20 questionnaires completed by patients at 3 monthly intervals up to 24 months | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Contacts
Public ContactKatie Worrallo
Outcome results
None listed