Protein acetylation as a diet-modifiable biomarker of colorectal cancer risk

Protein acetylation as a diet-modifiable biomarker of colorectal cancer risk: an interventional single-centre cross-section trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN90852168

Enrollment

140

Registered

2009-08-04

Start date

2006-07-01

Completion date

Unknown

Last updated

2018-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer/bowel health Cancer Malignant neoplasm of rectosigmoid junction

Interventions

Volunteers with a low habitual consumption of non-starch polysaccharides (NSP) and resistant starch (RS) will be recruited to an 8-week high fibre intervention trial. Volunteers will be provided with

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 40 years and above, either sex for interventional arm and male only for cross-sectional arm 2. Adenoma, normal or cancer colon (30 of each group) 3. Body mass index (BMI) between 20 and 29 kg/m^2;Inclusion criteria: 1. Aged 40 years and above, either sex for interventional arm and male only for cross-sectional arm 2. Adenoma, normal or cancer colon (30 of each group) 3. Body mass index (BMI) between 20 and 29 kg/m^2

Exclusion criteria

Exclusion criteria: 1. Severe medical or psychiatric illness 2. Unable to understand or communicate effectively;Exclusion criteria: 1. Severe medical or psychiatric illness 2. Unable to understand or communicate effectively

Design outcomes

Primary

Measure	Time frame
Altered faecal short chain fatty acid (SCFA) production. In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.;Altered faecal short chain fatty acid (SCFA) production. In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.	—

Measure

Time frame

Altered faecal short chain fatty acid (SCFA) production. In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.;Altered faecal short chain fatty acid (SCFA) production. In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.

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Secondary

Measure	Time frame
1. Altered bowel crypt cytokinetics (proliferation, apoptosis and apoptosis regulators) 2. Identification of candidate biomarker acetylations In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.;1. Altered bowel crypt cytokinetics (proliferation, apoptosis and apoptosis regulators) 2. Identification of candidate biomarker acetylations In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.	—

Measure

Time frame

1. Altered bowel crypt cytokinetics (proliferation, apoptosis and apoptosis regulators) 2. Identification of candidate biomarker acetylations In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.;1. Altered bowel crypt cytokinetics (proliferation, apoptosis and apoptosis regulators) 2. Identification of candidate biomarker acetylations In the cross-sectional arm there is a single sampling timepoint and all primary and secondary measures are made at this point. For the intervention arm sampling is performed at baseline and after 8 weeks of intervention.

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Countries

United Kingdom

Contacts

Public Contact; ;

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Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 2, 2026