Inspiratory muscle training in people with Huntington's disease

Feasibility and benefit of Inspiratory Muscle Training in people with Huntington?s Disease: a pilot randomised controlled feasibility study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN90741776

Enrollment

Registered

2013-02-26

Start date

2011-10-03

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Huntington's disease Nervous System Diseases Huntington disease

Interventions

All subjects will carry out training of 30 breaths through the training device, two times per day, seven days per week. The resistance given to subjects in the training group will be 50% of their maxi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age > 18, either sex 2. Genetically confirmed HD 3. Capacity to give informed consent 4. Inspiratory muscle strength < 80% predicted for age and height 5. Maintenance of a stable medical regime for 4 weeks prior to initiation of study

Exclusion criteria

Exclusion criteria: 1. History of additional prior neurological condition, such as stroke 2. Uncontrolled psychiatric symptoms 3. History of spontaneous pneumothorax / unstable asthma / chronic respiratory condition

Design outcomes

Primary

Measure	Time frame
Inspiratory muscle strength, measured using sniff nasal inspiratory pressure at baseline and end of training.	—

Secondary

Measure	Time frame
1. Inspiratory muscle strength, measured using maximal inspiratory pressure at baseline and end of training 2. Cough strength, measured by peak cough flow at baseline and end of training 3. Functional activity, measured by 30 second sit to stand at baseline and end of training	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026