Exercise and fatty liver with moderate alcohol consumption

The effect of exercise on liver lipid in people with fatty liver with moderate alcohol intake

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN90597099

Enrollment

Registered

2015-01-22

Start date

2014-03-01

Completion date

Unknown

Last updated

2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Hepatology

Interventions

Participants will undergo five metabolic assessment visits to the research facility, interspersed by either 12 weeks of supervised exercise therapy or continue their normal care.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Fatty liver 2. Moderate alcohol consumption (18-42 units/week for men; 11-28 units/week for women) 3. Sedentary 4. The person's weight needs to be stable prior to entering the study 5. Aged over 18 6. Understanding of English Target Gender: Male & Female; Upper Age Limit 75 years; Lower Age Limit 18 years

Exclusion criteria

Exclusion criteria: 1. In vivo ferrous material preventing MRI examination 2. Glitazones (rosiglitazone and pioglitazone) are not permitted. All other insulin sensitising medication must be stable for previous 6 months 3. HBA1c >9.5 4. Current weight loss or change in drinking habits 5. Vitamin E (>400UI/day), PUFAs (>2g/day) and Ursodeoxycholic acid are not permitted 6. Currently taking drugs that can induce Steatosis/steatohepatitis: corticosteroids (parenteral administration only), amiodarone (Cordarone), Tamoxifen (Nolvadex), methotrexate (Rheumatrex, Trexall)

Design outcomes

Primary

Measure	Time frame
Liver lipids, abdominal fat content, insulin sensitivity, lipid oxidation and inflammation.; Timepoint(s): 12 weeks	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 10, 2026