Topic: Medicines for Children Research Network
Conditions
Interventions
Baseline 1,25(OH)2D levels will be measured. The alfacalcidol dose will be adjusted so as to keep the serum 1,25(OH)2D level in the normal range (40 ? 150 pmol/L). Levels will be checked every 4 weeks
Sponsors
Great Ormond Street Hospital for Children (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 30 children aged 5 to 18 years, either sex 2. CKD stage 5 (estimated glomerular filtration rate [GFR] less than 15 ml/min/1.73 m^2 or on dialysis)
Exclusion criteria
Exclusion criteria: 1. Smokers 2. Diabetics 3. Uncontrolled hypertension 4. Inflammatory disorders 5. Receiving anti-epileptic medications 6. Liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood samples taken at 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Scans annually or prior to transplant | — |
Countries
United Kingdom
Outcome results
None listed