Blood flow of the knee cap in patients with knee pain

Bone blood perfusion of the patella measured with non-invasive Near Infrared Spectroscopy in patients with patellofemoral pain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN90377123

Enrollment

Registered

2021-12-15

Start date

2022-02-01

Completion date

Unknown

Last updated

2023-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patellofemoral pain in young adults Musculoskeletal Diseases

Interventions

Bone blood perfusion will be measured with non-invasive Near InfraRed Spectroscopy (NIRS). The measurements will take place in two different postures, which usually provoke symptoms of knee pain in pa

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18-40 years 2. Diagnosis of patellofemoral pain for more than 3 months 3. No other specific knee conditions (ACL, meniscus, OA, jumpers knee) 4. Non-traumatic onset of PFP

Exclusion criteria

Exclusion criteria: 1. PFP due to trauma or post-surgery 2. Other specific knee conditions (ACL, meniscus, OA, jumpers knee)

Design outcomes

Primary

Measure	Time frame
Bone blood perfusion expressed as concentrations of oxygenated hemoglobin (O2Hb) and deoxygenated hemoglobin (HHb) measured using NIRS during the two conditions.	—

Secondary

Measure	Time frame
Measured at a single time point (baseline) unless otherwise stated: 1. Anterior Knee Pain Scale – Dutch Version (AKPS-DV), 13 item questionnaire 2. Tegner Score, 10 item level of physical activity 3. Blood pressure (mmHg), sphygmomanometer 4. Prepatellar skinfold thickness measured with Harpenden skinfold caliper 5. Patella width measured with caliper 6. Decline step-down test (DSDT) measuring pain-free flexion angle 7. Lower limb range of motion (LLROM) measuring soft tissue flexibility of the kinetic chain 8. Visual Analogue Scale (VAS) measuring pain intensity while performing protocol 1 and 2	—

Measure

Time frame

Measured at a single time point (baseline) unless otherwise stated: 1. Anterior Knee Pain Scale – Dutch Version (AKPS-DV), 13 item questionnaire 2. Tegner Score, 10 item level of physical activity 3. Blood pressure (mmHg), sphygmomanometer 4. Prepatellar skinfold thickness measured with Harpenden skinfold caliper 5. Patella width measured with caliper 6. Decline step-down test (DSDT) measuring pain-free flexion angle 7. Lower limb range of motion (LLROM) measuring soft tissue flexibility of the kinetic chain 8. Visual Analogue Scale (VAS) measuring pain intensity while performing protocol 1 and 2

—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026