The effect of optimization of the electrical synchronicity of both heart chambers on the blood flow and blood volumes in and around the heart, during and after a coronary bypass surgery, in patients with an impaired heart function based on asynchronous contraction of both heart chambers

Postoperative Hemodynamic Effects of Cardiac REsynchronization Therapy in cardiac surgery patients with impaired left ventricular function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN90330260

Enrollment

Registered

2014-05-16

Start date

2010-01-29

Completion date

Unknown

Last updated

2020-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure patients with ventricular dyssynchrony in cardiac surgery

Interventions

Medical history, physical examination, ECG, Echo-Doppler (see details), and preoperative laboratory data, which are included in the standard pre-operative care. Echo-Doppler measureme

left ventricular pacing and biventricular pacing. 4.4. Pacing sequence: 4.4.1. AV conduction present: AAI - DDD RV ? AAI - DDD LV ?AAI ?DDD BIV ? AAI 4.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 18 years or over 2. Patients scheduled for coronary artery bypass grafting surgery (CABG) and/or valve surgery 3. Left ventricular ejection fraction of 35% or less 4. Sinus rhythm with one of the following criteria: 4.1. QRS duration of > 130 ms and left bundle branch pattern 4.2. Pacemaker-dependent patients with right ventricular paced rhythm and QRS width of > 180 ms 4.3. Evidence of left ventricular dyssynchrony with Tissue Doppler Imaging (TDI) 5. Able to give informed consent

Exclusion criteria

Exclusion criteria: 1. Myocardial infarction within the past 3 months 2. A history of gastric or esophageal disease 3. Allergy to sulphur hexafluoride

Design outcomes

Primary

Measure	Time frame
Changes in left ventricular pressures, pulmonary blood volume, intrathoracic blood volume and total circulating blood volume after biventricular pacing in comparison with the patient?s own rhythm and right ventricular pacing.	—

Secondary

Measure	Time frame
Perioperative changes in hemodynamic performance after biventricular pacing.	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 18, 2026