Joint Hypermobility Musculoskeletal Diseases Hypermobility syndrome
Conditions
Interventions
Strength training for 12 weeks with two training sessions of about 50- 60 minutes weekly in a medical training fitness, totally 24 training sessions.
First two weeks: complex method,
Sponsors
Bern University Hospital (Switzerland)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women with generalized joint hypermobility 2. 20 to 40 years old 3. Normal body mass index (BMI) (between 18-30 kg/m2) 4. At least 6/9 points in the Beighton score 5. Right knee extension beyond 10° 6. Able to understand German questionnaires
Exclusion criteria
Exclusion criteria: 1. Surgery of the legs or lumbar spine in the last two years 2. Doing more than four hours per week of regular intense sports 3. Pregnancy or less than one year after delivery 4. Known genetic diseases of connective tissue like Marfan syndrome and Osteogenesis imperfecta, as well as Ehler-Dahnlos-syndrome I and II
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of strength training is the increase in muscle strength, measured as maximum isometric strength and the rate of force development (RFD) of knee extensors and knee flexors on a custom-built strength measurement table with a force transducer. Measured at baseline, after training respectively waiting period (12 weeks) and three months after end of the training. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ground reaction forces (GRF) and muscle activity (EMG) during stair ascent and descent: GRF measured with force plates on a custom-built six step standard stair at self-selected speed. EMG of following leg muscles with surface electrodes: vastus lateralis, vastus medialis, biceps femoris and semitendinosus. 2. Passive tibial translation: passive ventral displacement of the tibia against the femur in the ventral direction, measured with an adapted Aircast Rolimeter. 3. Peripheral quantitative computer tomography (pQCT): Muscle and bone variables measured at thigh and lower leg, as well as distal radius: Bone density of tibia, femur and radius, muscle cross-sectional area at thigh, calf and forearm. 4. Three questionnaires for pain and disability, as well as general health: 1. Medical Outcomes Study Short Form 36-Item (SF-36). 2. Arthritis Impact Measurement Scales 2 (AIMS-2). 3. Self-developed questionnaire for pain and disability in functional activities using 5 point likert-scales. GRF and EMG during stair climbing, tibial translation and pQCT will be measured at baseline, after training respectively waiting period (12 weeks) and three months after end of the training. The questionnaires will be filled in at all these time points and additionally six and twelve months after end of the training. | — |
Countries
Switzerland
Outcome results
None listed