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Randomised controlled trial comparing point-of-care testing for respiratory viruses with standard clinical care in adults hospitalised with acute respiratory illness

Comparison of point-of-care testing for respiratory viruses with standard clinical care in adults presenting to secondary care with acute respiratory illness (ResPOC): a randomised controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN90211642
Enrollment
720
Registered
2015-01-14
Start date
2015-01-15
Completion date
Unknown
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory illness Respiratory Acute respiratory illness

Interventions

Participants are enrolled and assigned a study number consequently. Patients are randomised 1:1 to the intervention or control groups using an online randomisation service (sealed envelope.com). Blind

Sponsors

University Hospital Southampton Foundation NHS Trust
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years old or over 2. Capacity to provide written informed consent and is able and willing to adhere to the study procedures 3. Is a patient at Southampton General Hospital Acute Medical Unit (AMU) or Emergency Department (ED) 4. Can be recruited to the study within 24 hours of first triage by ED staff or within 24 hours of arrival on AMU (if admitted directly to AMU) 5. Has an acute respiratory illness and/or fever >37.5°C 6. Duration of illness less than or equal to 7 days An episode of acute respiratory illness is defined as an acute pulmonary illness (including pneumonia, bronchitis and influenza-like illness) or an acute exacerbation of a chronic respiratory illness (including exacerbation of chronic obstructive pulmonary disease, asthma or bronchiectasis).

Exclusion criteria

Exclusion criteria: 1. A palliative approach is being taken by the treating clinicians 2. Previously included in this study (first season only) 3. Declines nasal or pharyngeal swabbing

Design outcomes

Primary

MeasureTime frame
Proportion of patients treated with antibiotics: measured retrospectively from case notes for the entire duration of hospitalisation or at 30 days, whichever is shortest

Secondary

MeasureTime frame
Secondary outcome measures as of 27/09/2016: The outcomes will be measured retrospectively from case notes for the entire duration of hospitalisation or at 30 days, whichever is shortest. 1. Duration of antibiotic use 2. Proportion of patients receiving only a stat dose of antibiotics 3. Proportion of patients receiving <48 hours antibiotics 4. Proportion of patients treated with antiviral drugs 5. Time to antiviral drug use 6. Duration of antiviral drugs 7. Duration of hospital stay 8. Proportion of patients nursed in a side room 9. Duration of side room use 10.Time to allocation of a side room 11. Health care utilisation Original secondary outcome measures: The outcomes will be measured retrospectively from case notes for the entire duration of hospitalisation or at 30 days, whichever is shortest. 1. Duration of antibiotic use 2. Proportion of patients treated with antiviral drugs 3. Time to antiviral drug use 4. Duration of antiviral drugs 5. Duration of hospital stay 6. Proportion of patients seen by a nurse in a side room 7. Time to allocation to a side room 8. Number of investigations done

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 11, 2026