A randomised clinical trial assessing the additional value of ovarian hyperstimulation in intrauterine insemination (IUI) for couples with an abnormal post-coital test (PCT)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN90142795

Enrollment

250

Registered

2006-02-08

Start date

2002-06-01

Completion date

Unknown

Last updated

2021-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subfertility Pregnancy and Childbirth Subfertility

Interventions

These couples were randomly allocated to three cycles of IUI with COH or three cycles of IUI without COH. Controlled ovarian hyperstimulation as well as ovulation detection induction, semen preparatio

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Couples were eligible if they had an abnormal PCT, either due to cervical hostility diagnosed by a well-timed, non-progressive PCT with normal semen parameters or due to a poor semen quality. The spontaneous pregnancy chance in the next year, leaving the result of the PCT out of consideration, was less than 30%.

Exclusion criteria

Exclusion criteria: All other subfertile couples.

Design outcomes

Primary

Measure	Time frame
The primary endpoint was ongoing pregnancy within three cycles of IUI. Ongoing pregnancy was defined as the presence of foetal cardiac activity at transvaginal sonography at a gestational age of at least 12 weeks.	—

Secondary

Measure	Time frame
Secondary endpoints were total number of clinical pregnancies, miscarriages and multiple pregnancies.	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026