Colorectal cancer Cancer Colorectal cancer
Conditions
Interventions
For patients having endoscopy, they will initially have their colonoscopy with white light as is standard practice. The fluorescent lectin is applied to any lesions identified with white light and an
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Male or female, aged 18 years or over 3. Patients undergoing endoscopic procedures including colonoscopy and flexible sigmoidoscopy as well as transanal endoscopic microsurgery (TEMS), including robotic assisted TEMS 4. In the investigator’s opinion, is able and willing to comply with all study requirements;Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Male or female, aged 18 years or over 3. Patients undergoing endoscopic procedures including colonoscopy and flexible sigmoidoscopy as well as transanal endoscopic microsurgery (TEMS), including robotic assisted TEMS 4. In the investigator’s opinion, is able and willing to comply with all study requirements
Exclusion criteria
Exclusion criteria: 1. Patient who is unable or unwilling to give informed consent 2. Female participant who is pregnant, lactating or planning pregnancy during the course of the trial. If there is an uncertainly regarding whether a woman could be pregnant, then they will be excluded from the study. 3. Patients with known egg allergies, ovalbumin allergy and soya allergies;Exclusion criteria: 1. Patient who is unable or unwilling to give informed consent 2. Female participant who is pregnant, lactating or planning pregnancy during the course of the trial. If there is an uncertainly regarding whether a woman could be pregnant, then they will be excluded from the study. 3. Patients with known egg allergies, ovalbumin allergy and soya allergies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Signal to background ratio after application of lectin is measured using the fluorescence ratio of WFA binding to normal versus dysplastic/early cancer tissue during endoscopic or surgical procedure 2. Detection rate of dysplastic and cancerous lesions compared to white light alone is measured as the number of lesions identified during endoscopic or surgical procedure and calculating the sensitivity and specificity ;1. Signal to background ratio after application of lectin is measured using the fluorescence ratio of WFA binding to normal versus dysplastic/early cancer tissue during endoscopic or surgical procedure 2. Detection rate of dysplastic and cancerous lesions compared to white light alone is measured as the number of lesions identified during endoscopic or surgical procedure and calculating the sensitivity and specificity | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures;No secondary outcome measures | — |
Countries
United Kingdom
Contacts
Public ContactThomas;Thomas Barnes;Barnes
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Outcome results
None listed