A feasibility study of early and enhanced rehabilitation in ICU

A feasibility study of early and enhanced rehabilitation in critical care and potential impact on immunoendocrine function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN90103222

Enrollment

Registered

2015-08-13

Start date

2015-06-01

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Critical care

Interventions

Patients are randomized to standard care or enhanced rehabilitation. 1. Standard care (control group): Regardless of the day of admission, all patients are assessed by

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =16 years 2. Patients who have received mechanical ventilation for = 5 days

Exclusion criteria

Exclusion criteria: 1. Profound neurological deficit 2. Orthopaedic patients with contraindications to mobilise (e.g. pelvic / spinal fractures) 3. Poor prior level of mobility ( 48 hours at another facility prior to admission 6. Expected withdrawal of treatment within the next 24 hours 7. Patients with already established rehabilitation pathways (e.g. amputees) 8. Previous participation in this study

Design outcomes

Primary

Measure	Time frame
Critical care and hospital length of stay	—

Secondary

Measure	Time frame
1. Efficacy: 1.1. Manchester Mobility Score at baseline and critical care discharge – This will highlight any differences seen in baseline mobility at the point of recruitment and track any functional changes achieved within critical care by the intervention strategies 1.2. Ventilator days – To assess whether the intervention and any associated physical improvements lead to an earlier liberation from ventilatory support. 1.3. ICU, Hospital and 2 year mortality – It has been suggested that improving physical status and reducing ICU length of stay may serve to reduce mortality both within critical care and the hospital. 1.4. Total hospital length of stay – To assess whether enhanced rehabilitation services within critical care and continuing onto the wards can also reduce the post-ICU length of stay. 2. Patient focused outcomes: 2.1. Functional status: Barthel index score at baseline (estimated), critical care discharge, hospital discharge, 3 and 12 months – To assess the impact of the rehabilitation programmes on function during activities of daily living at hospital discharge and through the post-discharge period. 2.2. Health related quality of life: SF36 at baseline (estimated), critical care discharge, hospital discharge, 3 and 12 months - to assess whether enhanced rehabilitation programmes improve patient-reported measures of health status. 2.3. Anxiety and depression: HADS score – at critical care and hospital discharge – to assess whether structured programmes of rehabilitation improve the psychological impact of critical illness and recovery. 3. Mechanism: 3.1. Muscle thickness of quadriceps, thenar eminence, biceps and rectus abdominus – to assess whether enhanced physiotherapy attenuates the reduction in muscle thickness seen in critical illness 3.2. Serum Cortisol:DHEAS ratios – to a	—

Measure

Time frame

1. Efficacy: 1.1. Manchester Mobility Score at baseline and critical care discharge – This will highlight any differences seen in baseline mobility at the point of recruitment and track any functional changes achieved within critical care by the intervention strategies 1.2. Ventilator days – To assess whether the intervention and any associated physical improvements lead to an earlier liberation from ventilatory support. 1.3. ICU, Hospital and 2 year mortality – It has been suggested that improving physical status and reducing ICU length of stay may serve to reduce mortality both within critical care and the hospital. 1.4. Total hospital length of stay – To assess whether enhanced rehabilitation services within critical care and continuing onto the wards can also reduce the post-ICU length of stay. 2. Patient focused outcomes: 2.1. Functional status: Barthel index score at baseline (estimated), critical care discharge, hospital discharge, 3 and 12 months – To assess the impact of the rehabilitation programmes on function during activities of daily living at hospital discharge and through the post-discharge period. 2.2. Health related quality of life: SF36 at baseline (estimated), critical care discharge, hospital discharge, 3 and 12 months - to assess whether enhanced rehabilitation programmes improve patient-reported measures of health status. 2.3. Anxiety and depression: HADS score – at critical care and hospital discharge – to assess whether structured programmes of rehabilitation improve the psychological impact of critical illness and recovery. 3. Mechanism: 3.1. Muscle thickness of quadriceps, thenar eminence, biceps and rectus abdominus – to assess whether enhanced physiotherapy attenuates the reduction in muscle thickness seen in critical illness 3.2. Serum Cortisol:DHEAS ratios – to a

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Countries

United Kingdom

Contacts

Public ContactLauren Cooper

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 10, 2026