Post-operative morbidity Surgery Post-operative morbidity
Conditions
Interventions
informed consent
demographic data collection
Visit 1 (within 3 weeks): cardiopulmonary exercise test
blood samples, microvascular and cardiopulmonary data collected pre- and 60 minutes post-exercise
Visit 2 (post-operative day 2): blood samples, microvascular and cardiopulmonary data collected pre- a
Sponsors
University College London Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing major elective major surgical procedures that are associated with a high incidence of post-operative morbidity (abdominal/oesophageal/hepatic resection/gynaecology/urological reconstructive surgery) and who meet the following criteria: 1. American Society of Anaesthesiologists (ASA) risk grade 3 - 4 2. Aged greater than 50 years, either sex
Exclusion criteria
Exclusion criteria: 1. Acute myocardial ischaemia (contraindication for inotropic support) 2. Acute arrhythmias (contraindication for inotropic support) 3. Pregnancy (lithium-based cardiac output monitoring device) 4. Patients receiving palliative treatment only
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morbidity on post-operative day 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune, bioenergetic, microcirculatory and cellular correlates associated with development of post-operative morbidity and length of hospital stay | — |
Countries
United Kingdom
Outcome results
None listed