UK Pregnancies Better Eating and Activity Trial

Conditions

Obesity during pregnancy Nutritional, Metabolic, Endocrine Obesity

Sara L. White, Dharmintra Pasupathy, Shahina Begum, Naveed Sattar, Scott M. Nelson et al. (7 authors)

PLoS ONE2022-12-306 citations

10.1371/journal.pone.0279642

Lifestyle intervention in obese pregnancy and cardiac remodelling in 3-year olds: children of the UPBEAT RCT

Paul Taylor, Haotian Gu, Hannah Saunders, Federico Fiori, Kathryn V. Dalrymple et al. (100 authors)

International Journal of Obesity2022-10-1213 citations

10.1038/s41366-022-01210-3

Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial

Elie Antoun, Negusse Kitaba, Philip Titcombe, Kathryn V. Dalrymple, Emma Garratt et al. (17 authors)

PLoS Medicine2020-11-0597 citations

10.1371/journal.pmed.1003229

The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial.

Mills HL, Patel N, White SL, Pasupathy D, Briley AL, Santos Ferreira DL, Seed PT, Nelson SM, Sattar N, Tilling K, Poston L, Lawlor DA, UPBEAT Consortium.

2019-01-2149 citations

10.1186/s12916-018-1248-7

Do elevated symptoms of depression predict adherence and outcomes in the UPBEAT randomised controlled trial of a lifestyle intervention for obese pregnant women?

Molyneaux E, Begum S, Briley AL, Seed PT, Howard LM, Poston L, UPBEAT consortium.

2018-09-189 citations

10.1186/s12884-018-2004-x

Improving pregnancy outcome in obese women: the UK Pregnancies Better Eating and Activity randomised controlled Trial

Lucilla Poston, Ruth Bell, Annette Briley, Keith M. Godfrey, Scott M. Nelson et al. (13 authors)

Programme Grants for Applied Research2017-04-0121 citations

10.3310/pgfar05100

Dietary patterns in obese pregnant women; influence of a behavioral intervention of diet and physical activity in the UPBEAT randomized controlled trial

Angela C. Flynn, Paul T. Seed, Nashita Patel, Suzanne Barr, Ruth Bell et al. (15 authors)

International Journal of Behavioral Nutrition and Physical Activity2016-11-2867 citations

10.1186/s12966-016-0450-2

Change in level of physical activity during pregnancy in obese women: findings from the UPBEAT pilot trial.

Hayes L, Mcparlin C, Kinnunen TI, Poston L, Robson SC, Bell R, UPBEAT Consortium.

2015-03-0128 citations

10.1186/s12884-015-0479-2

Efficacy of metformin in pregnant obese women: a randomised controlled trial

Carolyn Chiswick, Rebecca M. Reynolds, Fiona C. Denison, Sonia Whyte, Amanda J. Drake et al. (12 authors)

BMJ Open2015-01-0120 citations

10.1136/bmjopen-2014-006854

A complex intervention to improve pregnancy outcome in obese women; the UPBEAT randomised controlled trial.

Briley AL, Barr S, Badger S, Bell R, Croker H, Godfrey KM, Holmes B, Kinnunen TI, Nelson SM, Oteng-Ntim E, Patel N, Robson SC, Sandall J, Sanders T, Sattar N, Seed PT, Wardle J, Poston L.

2014-02-1868 citations

10.1186/1471-2393-14-74

Developing a complex intervention for diet and activity behaviour change in obese pregnant women (the UPBEAT trial); assessment of behavioural change and process evaluation in a pilot randomised controlled trial.

Poston L, Briley AL, Barr S, Bell R, Croker H, Coxon K, Essex HN, Hunt C, Hayes L, Howard LM, Khazaezadeh N, Kinnunen T, Nelson SM, Oteng-Ntim E, Robson SC, Sattar N, Seed PT, Wardle J, Sanders TA, Sandall J.

2013-07-1595 citations

10.1186/1471-2393-13-148

Interventions

Current interventions as of 0/06/2012: The intervention is delivered by a health trainer in weekly sessions between 20 and 28 weeks' gestation and focusses on changing the diet (lowering the glycemic

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Willing and able to give informed consent 2. Pregnant women with booking body mass index (BMI) greater than or equal to 30 kg/m^2 3. Singleton pregnancy

Exclusion criteria

Exclusion criteria: Current exclusion criteria as of 06/06/2012: 1. Unwilling or unable to give informed consent 2. Pregnant women with booking BMI less than 30 kg/m^2 3. Multiple pregnancy 4. Pre-existing diabetes mellitus 5. Pre-existing hypertension requiring treatment, pre-existing thyroid and renal disease, current psychosis, sickle cell disease, thalassemia, coeliac disease Previous exclusion criteria: 1. Unwilling or unable to give informed consent 2. Pregnant women with booking BMI less than 30 kg/m^2 3. Multiple pregnancy 4. Pre-existing diabetes mellitus

Design outcomes

Primary

Measure	Time frame
Current primary outcome measure(s): 1. Maternal: GDM by HAPO criteria. 2. Infant: macrosomia (>90th customised birthweight centile). Previous primary outcome measure(s): Improved maternal glucose sensitivity, assessed at recruitment (10 - 16 weeks), and again in the third trimester (32 - 36 weeks).	—

Secondary

Measure	Time frame
Current secondary outcome measure(s): 1. Maternal: complications in pregnancy (inc GDM, pre-eclampsia, depression, quality of life), physical activity, diet, gestational weight gain, maternal body composition (skin folds), mode of delivery, hospital admissions. Health economic assessment. 2. Infant: adverse outcomes, neonatal unit admissions, SGA, LGA, body composition (skin folds). 3. At 6 months post partum: maternal and child diet and physical activity. Maternal general health (inc depression, quality of life). Maternal and child body composition. Childhood modifiers/modulators of obesity. 4. 3 years: To be confirmed; measures of maternal and child body composition, diet, physical activity. Childhood mental health, cardiovascular function. Previous secondary outcome measure(s): Reduction in foetal, maternal and pregnancy complications, assessed at recruitment (10 - 16 weeks), and again in the third trimester (32 - 36 weeks).	—

Measure

Time frame

Current secondary outcome measure(s): 1. Maternal: complications in pregnancy (inc GDM, pre-eclampsia, depression, quality of life), physical activity, diet, gestational weight gain, maternal body composition (skin folds), mode of delivery, hospital admissions. Health economic assessment. 2. Infant: adverse outcomes, neonatal unit admissions, SGA, LGA, body composition (skin folds). 3. At 6 months post partum: maternal and child diet and physical activity. Maternal general health (inc depression, quality of life). Maternal and child body composition. Childhood modifiers/modulators of obesity. 4. 3 years: To be confirmed; measures of maternal and child body composition, diet, physical activity. Childhood mental health, cardiovascular function. Previous secondary outcome measure(s): Reduction in foetal, maternal and pregnancy complications, assessed at recruitment (10 - 16 weeks), and again in the third trimester (32 - 36 weeks).

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Countries

England, United Kingdom

Outcome results

None listed