Does ischaemic pre-conditioning reduce renal damage during elective infra-renal aortic aneurysm repair? Randomised controlled trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN89918035

Enrollment

Registered

2005-11-15

Start date

2005-11-14

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal aortic aneurysm Circulatory System Aortic aneurysm

Interventions

Participants will be randomised to undergo clamping or not. The intervention consists of application of a crossclamp to each common iliac artery for 10 minutes followed by 10 minutes reperfusion time

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing elective open repair of an infra-renal abdominal aortic aneurysm.

Exclusion criteria

Exclusion criteria: 1. Pre-existing renal failure 2. Baseline serum creatinine >150 µmols/l 3. Baseline serum urea >20 mmols/l 4. Previous history of acute renal failure 5. Previous renal transplant 6. Previous renal disease 7. Previous endovascular aneurysm repair 8. Previous renal replacement therapy 9. Suprarenal aneurysm 10. Ankle-brachial pressure index <0.7

Design outcomes

Primary

Measure	Time frame
1. Post-operative urinary albumin-creatinine ratios 2. Post-operative creatinine clearance 3. Post-operative glomerular filtration rate	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026