Organophosphate poisoning Injury, Occupational Diseases, Poisoning Poisoning
Conditions
Interventions
Four dose levels of clonidine will be studied with the dose increased if the results in the preceding sixteen patients do not indicate any concerning dose-related adverse effects. Four patients will r
Sponsors
South Asian Clinical Toxicology Research Collaboration (SACTRC) (Sri Lanka)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients (male or female, aged 16 years or older) with symptomatic acute OP poisoning.
Exclusion criteria
Exclusion criteria: 1. Patients who do not consent 2. Pregnant women 3. Patients less than 16 years of age 4. Patients who are hypotensive (blood pressure less than 90/50 mmHg) on presentation 5. Patients who have ingested other substances in addition to OP 6. Patients with other major medical conditions (e.g. cardiovascular disease, renal or hepatic failure)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the number of patients requiring ventilation or dying in those receiving clonidine versus the placebo group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will include: 1. Need for ventilation 2. Blood pressure 3. Level of consciousness 4. Duration of atropine therapy 5. Death 6. Adverse events reported by doctors will be rated by them as to the likelihood of them being due to Clonidine bolus or infusion (certain, probable, possible, unlikely) | — |
Countries
Sri Lanka
Outcome results
None listed