A pilot study of a trial of tight control of blood pressure during hip fracture surgery in older people

Hip fracture intervention study for prevention of hypotension (HIP-HOP) trial: pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN89812075

Enrollment

Registered

2016-08-30

Start date

2016-10-01

Completion date

Unknown

Last updated

2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Specialty: Injuries and emergencies, Primary sub-specialty: Injuries and emergencies

Interventions

Participants are randomised to one of two groups in blocks of unequal size, stratified by intended mode of anaesthesia and Nottingham Hip Fracture Score (=4 vs >4). Participants in both groups will

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged over 70 years 2. Unilateral hip fracture requiring hemiarthroplasty, dynamic hip screw, proximal femoral nail fixation 3. Able to provide consent for trial participation

Exclusion criteria

Exclusion criteria: 1. Patients due to undergo total hip arthroplasty 2. Patients with peri-prosthetic fractures 3. Patients without capacity 4. Pre-operative elevated troponin (measured for clinical reasons)

Design outcomes

Primary

Measure	Time frame
Composite of presence or absence of defined cardiovascular, renal and delirium morbidity is measured daily for 7 days post-surgery using blood testing, clinical observations, and medical record review.	—

Secondary

Measure	Time frame
Clinical outcomes: 1. Presence or absence of each of defined cardiovascular, renal and delirium morbidity is measured daily for 7 days post-surgery using blood testing, clinical observations, and medical record review 2. Prevalence bone cement implantation syndrome will be measured using the Donaldson grading tool recorded during anaesthesia and surgery 3. Postoperative mortality is measured 5 and 30 days, and 1 year through medical record review 4. Quality of life is measured using the EQ-5D questionnaire 30 days post-surgery Feasibility outcomes: 1. Recruitment rate is recorded as the number of eligible participant who consent to participate in the study by 12 months 2. Protocol efficacy will be measured by recording arterial blood pressure intraoperatively and determining 2.1. The lowest arterial blood pressure (systolic, mean and diastolic) value following induction of anaesthesia; and 2.2. Time below threshold values (Mean arterial pressure 75mmHg, 80% pre-op mean arterial pressure)	—

Measure

Time frame

Clinical outcomes: 1. Presence or absence of each of defined cardiovascular, renal and delirium morbidity is measured daily for 7 days post-surgery using blood testing, clinical observations, and medical record review 2. Prevalence bone cement implantation syndrome will be measured using the Donaldson grading tool recorded during anaesthesia and surgery 3. Postoperative mortality is measured 5 and 30 days, and 1 year through medical record review 4. Quality of life is measured using the EQ-5D questionnaire 30 days post-surgery Feasibility outcomes: 1. Recruitment rate is recorded as the number of eligible participant who consent to participate in the study by 12 months 2. Protocol efficacy will be measured by recording arterial blood pressure intraoperatively and determining 2.1. The lowest arterial blood pressure (systolic, mean and diastolic) value following induction of anaesthesia; and 2.2. Time below threshold values (Mean arterial pressure 75mmHg, 80% pre-op mean arterial pressure)

—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 26, 2026