Chronic fatigue syndrome Nervous System Diseases Encephalitis, myelitis and encephalomyelitis
Conditions
Interventions
Patients will receive routine clinical care including withdrawal of potential culprit medications, and conservative and abortive advice as is our usual practice. Following full written consent they wi
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) patients 2. Both males and females, aged 18 years and over 3. Patients who fulfil the Fukuda diagnostic criteria 4. Patients with an autonomic phenotype, i.e., have a composite autonomic symptom scale of greater than 32.5
Exclusion criteria
Exclusion criteria: 1. Inability to give informed consent 2. Patients on drugs which can affect the autonomic nervous system which cannot be discontinued safely 3. Inability to stand for up to 40 minutes due to muscular or neurological disorders, cardiac transplantation, or pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Study compliance. Timepoints: 1 week, 4 weeks, 6 months. 2. Autonomic function. Timepoints: baseline, 1 week, 4 weeks, 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatigue. Timepoints: baseline, 1 week, 4 weeks, 6 months. | — |
Countries
United Kingdom
Outcome results
None listed