Topic: Stroke Research Network
Conditions
Interventions
Baseline investigations include blood pressure measurement using UA-767 monitor, modified Rankin Score, Barthel Index, National Institutes of Health Stroke Score and Oxfordshire Community Stroke Proje
Sponsors
University Hospitals of Leicester NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged greater than or equal to 18 years, either sex 2. Stroke onset greater than or equal to 48 hours (for suspected stroke, onset time is last time patient was asymptomatic) 3. Clinical diagnosis of suspected stroke by neuroimaging before or after study entry to exclude non-stroke diagnoses and define stroke type 4. Currently receiving antihypertensive treatment and within 48 hours or last dose 5. Informed patient consent or relative/carer consent
Exclusion criteria
Exclusion criteria: 1. Hypertensive encephalopathy 2. Hypertension greater than 200/120 mmHg in association with intracerebral haemorrhage 3. Co-existing cardiac or vascular emergency 4. Contraindications to stopping antihypertensive therapy 5. Impaired conscious level 6. Dysphagia 7. Premorbid dependence 8. Co-existing life-threatening condition with life expectancy less than 6 months 9. Females of child-bearing potential 10. Non-stroke diagnoses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death or dependancy (modified Rankin Score greater than 3) at 2 weeks post-randomisation | — |
Secondary
| Measure | Time frame |
|---|---|
| Early outcomes, measured at 2 weeks and 6 months: 1. Neurological deterioration 2. Functional status 3. Blood pressure changes from admission and discharge Late outcomes: 4. Death and dependency 5. Fatal and non-fatal stroke recurrence 6. Functional status 7. Health-related quality of life | — |
Countries
United Kingdom
Outcome results
None listed