Analysis of Pediatric Pancreatitis - APPLE trial

Analysis of Pediatric Pancreatitis (APPLE): a cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN89664974

Enrollment

300

Registered

2015-02-12

Start date

2015-02-15

Completion date

Unknown

Last updated

2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute pancreatitis Nutritional, Metabolic, Endocrine Acute pancreatitis

Interventions

No interventions

Eligibility

Sex/Gender

All

Age

0 Years to 17 Years

Inclusion criteria

Inclusion criteria: 1. Acute pancreatitis 2. Age < 18 years old 3. Presenting at the emergency department of a hospital

Exclusion criteria

Exclusion criteria: Age > 18 years old

Design outcomes

Primary

Measure	Time frame
1. Develop a simple and accurate clinical scoring system to stratify children with acute pancreatitis during the first 6–12 hours of hospitalization according to their risk of a severe disease course: simple data (e.g. medical history, physical examination, laboratory tests and diagnostic imaging ) will be collected, recorded and statistically analyzed to assess their potential correlation with the disease severity 2. Specify the genetic background: mutations in the genes PRSS1, CTRC, CPA1, CFTR and SPINK1 will be sequenced 3. Recognize better the course of the pediatric pancreatitis Data will be analyzed at 3 months.	—

Measure

Time frame

1. Develop a simple and accurate clinical scoring system to stratify children with acute pancreatitis during the first 6–12 hours of hospitalization according to their risk of a severe disease course: simple data (e.g. medical history, physical examination, laboratory tests and diagnostic imaging ) will be collected, recorded and statistically analyzed to assess their potential correlation with the disease severity 2. Specify the genetic background: mutations in the genes PRSS1, CTRC, CPA1, CFTR and SPINK1 will be sequenced 3. Recognize better the course of the pediatric pancreatitis Data will be analyzed at 3 months.

—

Countries

Belarus, Bosnia and Herzegovina, Czech Republic, Estonia, Finland, Germany, Hungary, Italy, Latvia, Moldova, Poland, Romania, Russian Federation, Serbia, Slovakia, Slovenia, Spain, Sweden, Türkiye, Ukraine, United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 16, 2026