Atrial fibrillation Circulatory System Atrial fibrillation
Conditions
Interventions
Observational trial:
The included patients will undergo a radiofrequency ablation procedure comprising:
1. A CARTO-guided left atrial circumferential ablation
Sponsors
Medical University of Vienna (Austria)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Genders eligible for study: both 2. Age older than 18 years 3. Symptomatic, drug-resistant paroxysmal atrial fibrillation (self-terminating episodes lasting less than 7 days) 4. Patients referred to our department for catheter ablation of atrial fibrillation 5. Adequate anticoagulation for at least 1 month prior to admission (oral anticoagulation (target International Normalised Ratio [INR] 2 to 3) or treatment with weight-adjusted low-molecular-weight heparin
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Ongoing infections 3. Intracardiac thrombosis detected by trans-oesophageal echocardiography 4. Contraindications to anticoagulation 5. History of myocardial infarction or cardiac surgery within the last 3 months prior to admission 6. Pacemaker or other contraindications to Magnetic Resonance Imaging (MRI) 7. Denial or withdrawal of informed consent 8. Life expectancy less than 1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Biochemical markers of inflammation, oxidative stress and wound healing at the above specified timepoints 2. Ablation-induced structural atrial changes evaluated by MRI and echocardiography at the above specified timepoints | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlation of the assessed biochemical markers with ablation-induced structural changes, energy application data and AF recurrence rate after ablation 2. Complications | — |
Countries
Austria
Outcome results
None listed