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Regulatory mechanisms of high-polyphenol dietary intervention on exercise-induced immunosuppression during high-intensity training periods in adolescent athletes

Regulatory mechanisms of high-polyphenol dietary intervention on exercise-induced immunosuppression during high-intensity training periods in adolescent athletes: a systems biology analysis based on immune-metabolic pathways

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN89562119
Enrollment
80
Registered
2026-05-19
Start date
2024-09-15
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise-induced immunosuppression in adolescent athletes during periods of high-intensity training, particularly immune homeostasis disruption, reduced mucosal immune protection, inflammatory and oxidative stress responses, altered T-cell balance, gut microbiome changes, and increased susceptibility to upper respiratory tract infections. Other

Interventions

Participants were randomly allocated in a 1:1 ratio to either the high-polyphenol dietary intervention group or the placebo group. Randomisation was stratified by sex, sport discipline, and baseline i

Sponsors

Chizhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 17 Years

Inclusion criteria

Inclusion criteria: Adolescent athletes aged 15–17 years who met all of the following criteria: 1. At least 3 years of systematic training experience 2. Participation in provincial-level competition within the previous 12 months 3. Weekly training volume of =10 hours 4. Tanner stage III–V pubertal development

Exclusion criteria

Exclusion criteria: 1. An acute infection within the previous 4 weeks 2. Chronic inflammatory or autoimmune disease 3. Regular medication or supplement use that could affect immune function 4. A history of overtraining syndrome 5. A musculoskeletal injury that prevented normal training

Countries

China

Contacts

Public ContactLei He
1140907063@qq.com+8201058363886

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 11, 2026