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Effectiveness of the enzyme linked immuno-sorbent assay (ELISA) test for the prevention of migraine

A randomised controlled trial of food elimination diet based on the enzyme linked immuno-sorbent assay (ELISA) test for food sensitivity for the prevention of migraine

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN89559672
Enrollment
172
Registered
2009-03-13
Start date
2008-03-25
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine Nervous System Diseases Migraine

Interventions

Participants with a positive ELISA test (that is they have at least one food intolerance) will be randomised to one of two groups, either the True Diet (treatment) or Sham Diet (control) group. The Tr

Sponsors

University of York (UK) - York Trials Unit
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Between the ages of 18 - 65 years, either sex 2. Have had two or more migraine attacks (or four or more headache days) in the previous 4 week period 3. Have no other significant co-existing pathology, e.g. have had or currently suffering from an eating disorder (anorexia nervosa/bulimia nervosa)

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

MeasureTime frame
Change in number of headache days over the 12 week period. The Migraine Disability Assessment (MIDAS) Questionnaire will be used for this outcome - "On how many days in the last four weeks did you have a headache? (If a headache lasted more than 1 day, count each day)" at baseline, 4 weeks, 12 weeks and 16 weeks.

Secondary

MeasureTime frame
Measured at baseline, 4 weeks, 12 weeks and 16 weeks: 1. Total MIDAS score 2. Six-item Total Headache Impact Test (HIT-6) score 3. Number of migraine days

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026