Syndrome of inappropriate antidiuresis secondary to pneumonia Respiratory Syndrome of inappropriate antidiuresis secondary to pneumonia
Conditions
Interventions
Once informed consent has been acquired, participants are randomised to either fluid restriction or 0.9% saline infusion using a computer generated randomisation table using random permutated blocks o
Sponsors
Beaumont Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age > 18 years 2. Eu-volemic 3. New asymptomatic hyponatraemia with plasma sodium 120 - 130 mmol/L 4. Biochemical confirmation of SIAD, including exclusion of adrenal insufficiency and hypothyroidism. 5. Radiographic confirmation of pneumonia 6. Clinical confirmation of pneumonia 7. Systolic blood pressure > 100 mmHg
Exclusion criteria
Exclusion criteria: 1. Symptomatic or severe hyponatraemia (plasma sodium < 120 mmol/L) 2. Volume depletion / hypovolaemia / systolic BP < 100 mmHg 3. CCF 4. Uncontrolled hyperglycemia 5. AKI 6. Diuretic therapy 7. Clinical imperative for intravenous fluids 8. Chronic hyponatraemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in plasma sodium from baseline to day 4 (plasma sodium is measured using ion-selective electrode) 2. Change in blood pressure from baseline to day 4 (blood pressure is measured using amubulatory blood pressure monitoring on day 1 and day 3, and using office BP monitoring daily) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Proportion of patients achieving eunatraemia daily 2. Length of hospital stay, measured using the hospital database, up until time of discharge 3. Patient reported outcome (well-being), measured using the SF-12 and EQ-5D questionnaires, at baseline and day 4 | — |
Countries
Ireland
Outcome results
None listed