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A randomised controlled trial of radical radiotherapy alone versus radical surgery plus radical radiotherapy for patients with cancer of the oral cavity

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN89427989
Enrollment
Unknown
Registered
2001-07-01
Start date
1995-01-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and neck Cancer Head and neck

Interventions

1. Arm A: Radical radiotherapy to the primary tumour and to the anterior triangles of the neck. 2. Arm B: Radical surgery involving wide local excision of the intra oral tumour with approximately a 1

Sponsors

UK Co-ordinating Committee for Cancer Research (UKCCCR)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Histologically proven squamous cell carcinoma of all grades at one of the following sites (except any patient with disease stage T1 N0): Tongue; Floor of mouth/alveolus; Retromolar trigone; Tonsil/lateral pharyngeal wall 2. Aged >18 years 3. No evidence of distant metastases beyond the regional neck nodes in the neck 4. No other malignancy, except basal cell carcinomas of the skin or intraepithelial carcinoma of the cervix 5. WHO performance status 0-2 6. Fit for radical surgery

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration—

Secondary

MeasureTime frame
Not provided at time of registration—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026