A randomised controlled trial of warfarin vs aspirin for atrial fibrillation in an elderly (aged 75 and over) primary care population: Birmingham Atrial Fibrillation Treatment of the Aged study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN89345269

Enrollment

973

Registered

2000-10-23

Start date

1999-10-01

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation in primary care Circulatory System Atrial fibrillation

Interventions

Patients will be randomised to: 1. Aspirin 75 mg daily 2. Warfarin, target international normalized ratio (INR) 2.5 Follow-up: 1. Review of GP records at six monthly intervals 2. Annual patient q

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 75 or over 2. Non-rheumatic atrial fibrillation confirmed by electrocardiogram (ECG)

Exclusion criteria

Exclusion criteria: 1. Already on warfarin 2. History of major haemorrhage 3. Recent peptic ulcer disease (previous year) 4. Sensitivity to any of the study medications 5. Rheumatic heart disease

Design outcomes

Primary

Measure	Time frame
Fatal or non-fatal disabling stroke (ischaemic or haemorrhagic) or significant systemic embolism	—

Secondary

Measure	Time frame
1. Hospitalisation or death as a result of non-intracranial haemorrhage 2. Death (all cause) 3. Admission to hospital (all cause) 4. Quality of life (SF-12 & Euroqol 5D) 5. Disability (Rankin score)	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 7, 2026