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Thiopentone and ketamine versus isoflurane and fentanyl to maintain anaesthesia during cardiopulmonary bypass; effect on postoperative neuropsychological function. Neuropsychological Function after Coronary Artery Bypass Graft (CABG)

Thiopentone and ketamine versus isoflurane and fentanyl to maintain anaesthesia during cardiopulmonary bypass; effect on postoperative neuropsychological function. Neuropsychological Function after Coronary Artery Bypass Graft (CABG)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN89332886
Enrollment
Unknown
Registered
2003-09-12
Start date
2002-10-18
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery: Anaesthesia Surgery Anaesthesia

Interventions

Only the anaesthetist will be aware of which treatment is being given but they will not be involved in gathering the primary outcome data. Patients will undergo standard neuropsychological assessments

Sponsors

Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. All patients scheduled for elective CABG under the care of two surgical/anaesthetic teams 2. Under 80 years of age 3. Do not have porphyria, severe unstable coronary artery disease (UCAD) or who have hypersensitivity to any of the study drugs or central nervous system (CNS) disease.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Assessment of neurological outcome, mood, personality and quality of life and correlations with any change in neuropsychological function will be made.—

Secondary

MeasureTime frame
Not provided at time of registration—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026