The effect of transfusion on cerebral oxygenation in traumatic brain injury

The effect of transfusion on cerebral oxygenation in traumatic brain injury: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN89085577

Enrollment

Registered

2005-10-06

Start date

2002-07-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury Injury, Occupational Diseases, Poisoning Brain

Interventions

Blood transfusion - the patients are randomised to 3 different transfusion triggers

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Greater than 16 years of age 2. Severe traumatic brain injury (i.e. traumatic brain injury resulting in a resuscitated Glasgow coma score of less than or equal to 8, resulting in intracranial hypertension (greater than 20 mmHg for greater than 10 minutes), or requiring neurosurgical intervention 3. Informed assent from the next of kin

Exclusion criteria

Exclusion criteria: 1. Active haemorrhage 2. Active coronary ischaemia as judged by dynamic electrocardiogram (ECG) changes or positive troponin levels not due to myocardial contusion 3. Inability to place cerebral oxygenation monitors 4. Failure to fall below allocated transfusion threshold during intracranial pressure (ICP) monitoring

Design outcomes

Primary

Measure	Time frame
Brain tissue oxygen partial pressure.	—

Secondary

Measure	Time frame
1. Jugular venous saturation 2. Lactate/pyruvate ratio 3. Neurological outcome 4. Cerebral haemodynamics	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026