Multiple sclerosis Nervous System Diseases Multiple sclerosis
Conditions
Interventions
Three exercise groups will perform the same amount of exercise within sessions delivered in different ways:
1. Shorter and hard (anaerobic)
2. Longer and easy (aerobic)
3. A combination of both aerob
Sponsors
Oxford Brookes University (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults (over 18 years, either sex) with Multiple Sclerosis (MS) 2. Able to sit and pedal on a cycle ergometer and complete 60 seconds unloaded exercise 3. Ambulatory with/without a walking aid
Exclusion criteria
Exclusion criteria: 1. Serious medical condition or complication that would preclude safe exercise 2. Sudden change/relapse in MS 3. Cognitively unable to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Two-minute walk distance, measured at baseline, week 6 (half-way intervention), week 12 (end intervention) and week 24 (follow up). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Questionnaires: 1.1. Barthel Index of independence in activities of daily living 1.2. Fatigue Severity Scale (FSS): self reported fatigue levels 1.3. Physical Activity Questionnaire in the Elderly (PASE): self reported activity levels in home, work and social environments 1.4. General Health Status questionnaire - 36-item Short Form health survey (SF-36): Patient-completed health status measure 1.5. Short Orientation Memory Concentration scale (SOMC): measure of orientation, memory and concentration 1.6. Subjective vitality ?individual difference? scale: self reported energy levels scale 1.7. Self efficacy scale: confidence to take complete exercise scale 2. Anthropodmetry: weight (kg), height (m) and leg-length (cm) (anterior superior iliac spine to med. Malleolus) 3. Muscle performance: extensor leg power - measurement of leg extension power in sitting 4. Mobility: 4.1. Step count during 8 days measured with a Step Activity Monitor (watch sized device worn on ankle)* 4.2. Timed up and go test (sit to stand from chair and walk 5 metres) 4.3. During 2 minute walk test (walking characteristics (step time and length) recorded with a small accelerometer worn on back) 5. Hydration status: urine analysis 6. Blood test: of neurotrophic factors (proteins associated with brain function) and immune markers* 7. Fitness test: 7.1. Heart Rate (HR): heart rate monitor 7.2. Blood pressure: arm cuff measure 7.3. Rating of perception of effort and symptoms (Breathing and Leg effort): self report 7.4. Enjoyment S-bipolar scale: self report 7.5. Rate of oxygen consumption (metabolism): measurement of expired air 7.6. Muscle response to exercise (blood lactate levels): finger prick (capillary) blood samples 8. Qualative analysis of focus group meetings and interviews Secondary outcome measures will be measured at baseline, week 6 (half-way intervention), week 12 (end intervention) and week 24 (follow up). *Neurotrophic factors, immune markers and step activity will only be m | — |
Countries
United Kingdom
Outcome results
None listed