Topic: Metabolic and endocrine disorders
Conditions
Interventions
Participants will be given short-term diets lasting three days and will take part for a maximum of three consecutive weeks. These diets will contain specific test foods deemed to have high public heal
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-80 2. Male or female 3. Normal weight or overweight (body mass index 18.5-29.9 kg/m2)
Exclusion criteria
Exclusion criteria: 1. Weight change of more than 3kg in the preceding 2 months 2. Current smokers 3. Substance abuse 4. Excess alcohol intake 5. Pregnancy 6. Diabetes (Type 1 and Type 2) 7. Cardiovascular disease 8. Cancer 9. Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome 10. Kidney disease 11. Liver disease 12. Pancreatitis 13. Food allergy 14. Use of medications likely to interfere with energy metabolism, appetite regulation and hormonal imbalance, including but not exclusive to: antiinflammatory drugs (NSAIDs), steroids or other immunosuppressive medication, androgens, phenytoin, erythromycin or thyroid hormones Subjects with the above conditions/taking the above medications would have an altered pattern of hormones and inflammatory molecules because of their disease process which may lead to misleading results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clearly distinguishable metabolomic profiles for chosen foods/food groups, measured using mass spectrometry from samples collected on Days 1 - 5 of each study week | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Distinguishable metabolomic profiles for chosen foods when using minimally invasive urine sampling 2. Distinguishable metabolomic profiles for different food formulations Both measured using mass spectrometry from samples collected on Days 1 - 5 of each study week | — |
Countries
England, United Kingdom
Outcome results
None listed