Gastroenteritis Infections and Infestations Other gastroenteritis and colitis of infectious and unspecified origin
Conditions
Interventions
Participants will be randomised to one of two groups in a 1:1 ratio using an internet-based randomisation service using random permuted blocks of varying sizes (4, 6 and 8).
Intervention group: Part
Sponsors
University Hospital Southampton NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or over 2. Has the capacity to give informed, written consent and is able and willing to adhere to the study procedures 3. A patient in Southampton General Hospital ED, AMU, ASU or inpatient ward (if admitted directly to an inpatient ward) 4. Can be recruited to the study within a 48 hour period of first triage by ED staff OR within a 48 hour period of arrival on AMU or ASU or inpatient ward (if admitted directly to AMU/ASU to these areas) 5. Has an acute diarrhoeal illness and/or vomiting* 5. Has a duration of illness less of than or equal to 14 days *An episode of acute diarrhoea is defined as the passage of at least 3 loose stools for at least 1 day. (AMU = acute medical unit, ASU = acute surgical unit, ED = emergency department)
Exclusion criteria
Exclusion criteria: 1. Patients not fulfilling inclusion criteria 2. A palliative approach being taken by the treating clinicians 3. Previously included in this study and re-presenting within the last 30 days after hospital discharge 4. Declines to give stool sample and/or rectal swab Involvement in other research trials is not necessarily an exclusion criterion. Concurrent, prior or subsequent enrolment in an observational study is not expected to be an exclusion criterion, except at the discretion of the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of time in side room isolation is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Proportion of patients isolated in a side room is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 2. Time to patient isolation in a side room is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 3. Time to de-isolation in pathogen negative patients is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 4. Proportion of patients treated with antibiotics is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 5. Time to treatment with antibiotics is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 6. Duration of antibiotics is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 7. Duration of hospitalisation is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 8. Proportion of patients with a pathogen detected is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 9. Time to diagnosis is measured by retrospective review of case notes and electronic hospital information systems for the duration of hospitalisation (up to 30 days maximum) 10. Concordance between results obtained from rectal swab and stool culture is measured retrospectively at a time point >30 days post enrolment by comparing the result of diagnostic testing 11. Turnaround time is measured by retrospective | — |
Countries
England, United Kingdom
Outcome results
None listed