Lipid metabolism Nutritional, Metabolic, Endocrine Lipid metabolism
Conditions
Interventions
Randomisation process was via an online computer programme into 3 intervention arms.
3 oral lipid tolerance tests, with each differing in the amount of fat, or fat structure.
Sponsors
University of Leeds
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 18-70 years 2. Understanding of written English and ability to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Diagnosis, or current treatment, for issues relating to gut mobility or digestion 2. Diagnosis, or current treatment, for a haematological disorder 3. History of deep vein thrombosis 4. Heart attack or stroke =6 months prior to recruitment 5. History of, or current, malignancy 6. Pregnancy 7. Amenorrhoea or menopause 8. Allergies or dietary intolerances likely to be exacerbated by study procedures 9. Medical or psychiatric conditions likely to interfere with the study, as determined by the study investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to oral fat intake measured by blood triglyceride incremental Area Under the Curve (iAUC) from 0 to 360 minutes postprandially. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in cardiometabolic parameters (Platelet function and reactivity, cholesterol, lipoprotein and lipoprotein subclasses, and insulin) in response to oral fat intake measured by in whole blood and blood plasma via flow cytometry, an enzymatic method, ELISA, radioimmunoassay assessed from 0 to 360 minutes postprandially. | — |
Countries
England, United Kingdom
Outcome results
None listed