The effects of antenatal multiple micronutrient supplementation on birth weight, gestation and infection: a double blind, randomised controlled trial conducted in Nepal

Conditions

Low birth weight Neonatal Diseases Low birth weight

Dulal S, Liégeois F, Osrin D, Kuczynski A, Manandhar DS, Shrestha BP, Sen A, Saville N, Devakumar D, Prost A.

2018-02-289 citations

10.1136/bmjgh-2017-000527

Effect of antenatal multiple micronutrient supplementation on anthropometry and blood pressure in mid-childhood in Nepal: follow-up of a double-blind randomised controlled trial.

Devakumar D, Chaube SS, Wells JC, Saville NM, Ayres JG, Manandhar DS, Costello A, Osrin D.

2014-10-2231 citations

10.1016/s2214-109x(14)70314-6

Effects of antenatal multiple micronutrient supplementation on children's weight and size at 2 years of age in Nepal: follow-up of a double-blind randomised controlled trial.

Vaidya A, Saville N, Shrestha BP, Costello AM, Manandhar DS, Osrin D.

2008-02-01104 citations

10.1016/s0140-6736(08)60172-5

Effects of antenatal multiple micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial.

Osrin D, Vaidya A, Shrestha Y, Baniya RB, Manandhar DS, Adhikari RK, Filteau S, Tomkins A, Costello AM.

2005-03-01156 citations

10.1016/s0140-6736(05)71084-9

Interventions

Intervention arm (600 participants): Daily multiple micronutrient tablet from enrolment to delivery: Vitamin A 800 mcg, Vitamin E 10 mg, Vitamin D 5 mcg, Vitamin B1 1.4 mg, Vitamin B2

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Pregnant women attending for antenatal care at Janakpur Zonal Hospital, Dhanusha District, Nepal As of 15th February 2007 the following details were added to this trial record: 2. Enrolment at up to 20 weeks zero days gestation 3. Singleton pregnancy 4. No major foetal anomaly detected on obstetric ultrasound at enrolment 5. No pre-existing maternal illness that would be expected to affect foetal growth

Exclusion criteria

Exclusion criteria: Added 15/02/2007: 1. Pregnancy at gestations greater than 20 weeks zero days 2. Pre-existing maternal illness of a nature likely to affect pregnancy 3. Multiple pregnancy detected by obstetric ultrasound at enrolment 4. Residence potentially inaccessible for home follow-up

Design outcomes

Primary

Measure	Time frame
Added 15/02/2007: Primary outcomes (1200 participants): 1. Birth weight, length and head circumference measured within 72 hours of birth 2. Gestation at birth calculated on the basis of obstetric ultrasound biometry at enrolment	—

Secondary

Measure	Time frame
Added 15/02/2007: 1. Micronutritional Outcomes (200 participants): venous blood collected at 32 weeks gestation for measurement of plasma vitamins A, C, E and ferritin 2. Immunological outcomes (600 participants): 2.1. Clinical indicators of infection at every contact 2.2. Venous blood collected at 32 weeks gestation for measurement of neopterin 2.3. Breast milk collected at one month postpartum for measurement of sodium/potassium ratio	—

Measure

Time frame

Added 15/02/2007: 1. Micronutritional Outcomes (200 participants): venous blood collected at 32 weeks gestation for measurement of plasma vitamins A, C, E and ferritin 2. Immunological outcomes (600 participants): 2.1. Clinical indicators of infection at every contact 2.2. Venous blood collected at 32 weeks gestation for measurement of neopterin 2.3. Breast milk collected at one month postpartum for measurement of sodium/potassium ratio

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Countries

England, Nepal, United Kingdom

Outcome results

None listed