Cerebrovascular disease - transient ischaemic attack/minor strokes Circulatory System Transient cerebral ischaemic attacks and related syndromes
Conditions
Interventions
Although a single centre study, this trial is registered for ethical purposes as a two site study as recruitment occurs in a different site (Acute Hospital Trust) to the intervention (Primary Care Tru
Sponsors
Southampton University Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis (within 1 month of incident) of: 1.1. TIA - resolution of symptoms less than 24 hours of onset (not suspected patent foramen ovale [PFO]), or 1.2. Minor stroke - National Institutes of Health Stroke Scale (NIHSS) score less than 3 2. Lives within geographic locality (GP postcodes) 3. Independently mobile (can use stick but no falls within 2 months) 4. No significant visual/speech impairment 5. Cognitive capacity to undertake group exercises (no apparent dementia) 6. Able to give verbal and written consent 7. Aged greater than 18 years, either sex 8. Considered medically fit for exercise (Canadian Angina score and SIGN 2002 guidance) 9. No previous experience of cardiac rehabilitation 10. No current or recent participation in research
Exclusion criteria
Exclusion criteria: 1. TIA of suspected patent foramen ovale (hole in heart) origin with no other significant vascular risk factors 2. Live outside of the area covered by Southampton Cardiac Rehabilitation Team 3. Aphasia or other communication problems affecting ability to consent or to understand information given 4. Apparent dementia or significant cognitive impairment (mini-mental test [MMT] score less than 7) 5. Previously undertaken cardiac rehabilitation 6. Involved in current research or have recently been involved in any research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Risk Score: an algorithmic score that assesses the future risk of cardiac events based on age, sex, smoking status, resting blood pressure, diabetic status, total cholesterol and high-density/low-density lipoprotein cholesterol. Measured at baseline and 5 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at baseline and 5 months: 1. Biomarkers (C-reactive protein, fibrinogen) 2. Cardiovascular Disease Score: similar to the Cardiac Risk Score but allows for the identification of cerebrovascular risk 3. Exercise frequency: self-reported 4. Exercise capacity: maximal oxygen uptake (VO2) estimation derived from the Astrand-Rhyming cycle ergometer test (for participants not taking Beta Blockers) 5. Obesity: body mass index (BMI) and Waist-to-Hip ratio 6. Diet: quantity of fruit and vegetables consumed daily 7. Mood: Hospital Anxiety and Depression (HAD) score 8. Quality of Life: 36-item short form health survey (SF-36) 9. Qualitative analyses - purposive sampling of up to 10 participants from each arm with thematic analyses of semi-structured interviews | — |
Countries
United Kingdom
Outcome results
None listed