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Nitrous Oxide Sedation: How Long Must People Really Avoid Their Normal Activities

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN88442975
Enrollment
12
Registered
2004-05-11
Start date
2003-01-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation Surgery Sedation

Interventions

On three separate occasions, volunteers (N=12) received 100% oxygen or 20% or 40% N2O for 30 min. Dependent measures included the multiple sleep latency test (MSLT), a Drug Effects/Liking questionnai

Sponsors

The University of Chicago (USA)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Candidates who stated they were healthy, non-smoking, age 21-35 years, within 30% of ideal body weight and had normal sleeping habits were scheduled for a screening interview. Urine pregnancy tests were performed to ensure that female subjects were not pregnant. Subjects were asked to avoid depressants including ethanol (confirmed by measuring exhaled ethanol) and stimulants for 24 hours before study sessions. Subjects were formally admitted to the study if, after sleep latency testing, their average sleep latency was 10 min and they had no onsets of rapid eye movement (REM) sleep, which is indicative of narcolepsy.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration

Secondary

MeasureTime frame
Not provided at time of registration

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026